Abstract:

BACKGROUND: Deep vein catheter related infection is one of the serious complications of hemodialysis, which leads to the cessation of hemodialysis and even death of patients.
OBJECTIVE: To evaluate clinical effect of antibiotic-heparin lock therapy on prevention of deep vein catheter related infections in hemodialysis patients.
METHODS: 348 patients with chronic renal failure were randomly divided into experimental group and control group. After administration of deep vein catheter, ceftazidime-heparin lock therapy and heparin lock therapy were performed in experimental group and control group respectively. The incidences of catheter related infection, catheter blocking, local bleeding and unexpected catheter loss in two groups were recorded and compared.
RESULTS AND CONCLUSION: In the experimental group, incidence of catheter related infection was significantly lower than that in the control group (P=0.001). The incidences of blood stream infection and catheter colonization in experimental group were significantly lower than those in control group (P=0.017, P=0.026), but there was no significant difference in the incidence of local catheter related infection, blood stream infection and catheter colonization between the two groups (P=0.300, P=0.431, P=0.535, P= 0.634). Antibiotic-heparin lock therapy can significantly decrease the incidence of deep vein catheter related infections, which is an effective, safe and easy method with great potential in clinical application.